Imidazole derivatives having antimycotic and antibacterial...

Details Imidazole derivatives having antimycotic and antibacterial... Imidazole derivatives having antimycotic and antibacterial...

C - Chemistry, Metallurgy

07

D

167/223, 260/266

C07D 401/14 (2006.01) A61K 31/495 (2006.01) C07D 403/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1241654

- 16 - Abstract: IMIDAZOLE DERIVATIVES HAVING ANTIMYCOTIC AND ANTIBACTERIAL ACTIVITIES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Compounds of formula I Image (I) wherein R is a phenyl group; a phenyl group mono- or di- substituted by halogen atoms, methyl, methoxy, nitro, or trifluoromethyl group; or a 2-, 3- or 4-pyridyl group; and pharmaceutically acceptable acid addition salts thereof. Compounds I are prepared by reacting N-substituted piperazines with 1-(2',4'-dichloro-benzoylmetyl)-imidazo- le, optionally reducing thereafter the resulting enamines. Compounds I have antimycotic and antibacterial activities, higher than those of known comparison drugs.

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