Imidazole derivatives or salts thereof and drugs containing...

Details Imidazole derivatives or salts thereof and drugs containing... Imidazole derivatives or salts thereof and drugs containing...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/497 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07D 233/22 (2006.01) C07D 233/60 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2410391

Imidazole derivatives of the general formula (1) or salts thereof; and drugs containing the derivatives or the salts as the active ingredient wherein R1 and R2 are each aryl, heteroaryl, or the like; A, X1 and X2 are each N or CH; Y and Z are each O, S, or the like; R3, R4 and R5 are each hydrogen, alkyl, or the like; m is a number of 1 to 4; and n is a number of 0 to 4. These compounds exhibit excellent inhibitory activities against the production of NO and IL-6 and are useful in the prevention or treatment of diseases resulting from overdevelopment of NO and IL-6.

L'invention concerne des dérivés imidazole de formule générale (I) ou des sels de ces derniers, ainsi que des médicaments contenant comme principe actif lesdits dérivés ou lesdits sels, formule (I) dans laquelle R1 et R2 représentent tous deux aryle, hétéroaryle ou similaire; A, X1 et X2 représente chacun N ou CH ; Y et Z représentent chacun O, S ou similaire ; R3, R4 et R5 représentent chacun hydrogène, alkyle ou similaire ; m est un nombre compris entre 1 et 4 et n est un nombre compris entre 0 et 4. Ces composés présentent une excellente activité inhibitrice de la production de NO et d'IL-6 et sont très utiles dans la prévention ou le traitement de maladies induites par un développement exagéré de NO et d'IL-6.

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