Imidazole derivatives useful as inhibitors of faah

Details Imidazole derivatives useful as inhibitors of faah Imidazole derivatives useful as inhibitors of faah

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/41 (2006.01) A61K 31/4427 (2006.01) C07D 233/84 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2727245

The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.

La présente invention concerne certains dérivés imidazole qui sont utiles comme inhibiteurs de l'hydrolase des amides d'acides gras (FAAH). L'invention concerne également des formulations pharmaceutiques comprenant ces composés comme ingrédients actifs et l'utilisation des composés et de leurs formulations dans le traitement de certains troubles, comprenant l'ostéoarthrite, larthrite rhumatoïde, la neuropathie diabétique, l'algie post-zona, la douleur squeletto-musculaire, et la fibromyalgie, ainsi que la douleur aiguë, la migraine, le trouble du sommeil, la maladie dAlzheimer, et la maladie de Parkinson.

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