C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2753972
The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
La présente invention concerne certains dérivés d'imidazole pouvant être utilisés en tant que modulateurs de la FAAH (Fatty Acid Amide Hydrolase) et en tant qu'agents d'imagerie de la FAAH. L'invention concerne également des formes pharmaceutiques comprenant ces composés en tant qu'ingrédients actifs, ainsi que l'utilisation de ces composés et des formes pharmaceutiques en contenant pour le traitement de certaines affections, dont l'arthrose, la polyarthrite rhumatoïde, la neuropathie diabétique, les algies post-zostériennes, les douleurs musculo-squelettiques et la fibromyalgie, de même que les douleurs aiguës, les migraines, les troubles du sommeil, la maladie d'Alzheimer et la maladie de Parkinson.
Chioda Marc D.
Devita Robert J.
Hamill Terence G.
Li Wenping
Lin Linus S.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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