Imidazole kv1.5 potassium channel inhibitors

Details Imidazole kv1.5 potassium channel inhibitors Imidazole kv1.5 potassium channel inhibitors

C - Chemistry, Metallurgy

07

D

C07D 233/38 (2006.01) A61K 31/4166 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2655574

The present invention relates to 1-N-amino-2-imidazolidinones (I) and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial- selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

Cette invention concerne des 1-N-amino-2-imidazolidinones et des dérivés de ces substances qui agissent efficacement comme inhibiteurs de potassium Kv1.5 en tant qu'agents anti-arythmiques à sélectivité auriculaire. L'invention concerne également des compositions contenant des inhibiteurs du canal potassique Kv1.5 et des méthodes de traitement de l'arythmie cardiaque.

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