C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 17/14 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2761064
The present invention relates to a new compound of formula (I) wherein R1 is hydrogen or fluoro; R2 and R3 are independently selected from hydrogen or methyl; or a pharmaceutically acceptable salt thereof, pharmaceutical formulations containing said compound, to the use of said active compound in therapy, to the use for the treatment of conditions associated with glycogen synthase kinase-3 related disorders, such as Alzheimer's disease, as well as for the method of treatment of said disorders, comprising administering to a mammal, including human in need of such treatment, a therapeutically effective amount of said compound.
La présente invention porte sur un nouveau composé de formule (I) où R1 représente l'hydrogène ou le fluor; R2 et R3 sont indépendamment choisis parmi l'hydrogène ou le méthyle; ou un sel pharmaceutiquement acceptable associé, sur des formulations pharmaceutiques contenant ledit composé, sur l'utilisation dudit composé actif en thérapie, sur son utilisation pour le traitement d'états pathologiques associés à des troubles liés à la glycogène synthase kinase 3, tels que la maladie d'Alzheimer, ainsi que sur la méthode de traitement desdits troubles comprenant l'administration à un mammifère, notamment un humain nécessitant un tel traitement, d'une quantité thérapeutiquement efficace dudit composé.
Arvidsson Per I.
Nicholas Burrows Jeremy
Tjerneld Erica
Yngve Ulrika
Astrazeneca Ab
Fetherstonhaugh & Co.
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