C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/58 (2006.01) A61K 31/415 (2006.01) A61K 31/4174 (2006.01) C07D 233/64 (2006.01)
Patent
CA 2232467
This invention relates compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: (see figure I) wherein R1 is selected from H, C1-6alkyl and benzyl; R2 is selected from H and C1-6alkyl; R3 is selected from H and C1-6alkyl; R4 is selected from C1-6alkyl and halo; R5 is selected from H and OH; and salts, hydrates and solvates thereof. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of subtypes of the serotonin receptor is implicated, such as migraine.
L'invention porte sur des composés possédant une activité de fixation des récepteurs de la sérotonine, sur des compositions pharmaceutiques à base de ces composés, et sur leur emploi en médecine, notamment pour le traitement des troubles du SNC. On décrit ici des composés de formule générale (voir figure I), où R1 est choisi parmi un H, un alkyle C1-6 et un benzyle; R2 est choisi parmi un H et un alkyle C1-6; R3 est choisi parmi un H et un alkyle C1-6; R4 est choisi parmi un alkyle C1-6 et un halogène; R5 est choisi parmi un H et un OH. On décrit aussi leurs sels, hydrates et produits de solvatation. Enfin, on décrit l'utilisation de ces composés comme produits pharmaceutiques pour traiter des troubles dans lesquels se trouve impliquée la stimulation de sous-types des récepteurs de la sérotonine, notamment la migraine.
Ridout & Maybee Llp
Virginia Commonwealth University
LandOfFree
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