C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/36 (2006.01) A61K 31/4166 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2682649
The present invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders / diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.
L'invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci. Les composés ou les sels modulent la fonction récepteur de P2X7 et peuvent antagoniser les effets de ATP au niveau du récepteur de P2X7 (antagonistes du récepteur de P2X7). L'invention concerne également l'utilisation de ces composés ou sels, ou des compositions pharmaceutiques de ceux-ci dans le traitement ou la prévention de troubles/maladies médiés par le récepteur de P2X7, par exemple la douleur, l'inflammation ou une maladie neurodégénérative, en particulier la douleur telle que la douleur inflammatoire, la douleur neuropathique ou la douleur viscérale.
Beswick Paul John
Dean David Kenneth
Gleave Robert James
Moses Andrew Peter
Walter Daryl Simon
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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