Imidazolidine derivatives

Details Imidazolidine derivatives Imidazolidine derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 38/05 (2006.01) C07K 5/02 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2105014

The present invention relates to compounds of the general formula I Image in which R is hydrogen or (C1-C6)-alkyl, R1 is -(CH2)n-NH-X where n is an integer from 1 to 6 and X is, for example, hydrogen or (C1-C6)-alkyl, R2, R3 and R4 are each, for example, hydrogen, r is an integer. from 0 to 3, Y is -(CH2)m-CO- where m is an integer from 1 to 4, Z is oxygen or sulphur and W is, for example, hydroxyl. The compounds of the invention inhibit platelet aggregation, the metastasis of carcinoma cells and osteoclast binding to the bone surfaces. They are therefore useful in therapy and prophylaxis of vascular diseases, cancer and osteoporosis.

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