C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 167/237
C07D 471/20 (2006.01) A61K 31/415 (2006.01) C07D 487/10 (2006.01)
Patent
CA 1266270
IMIDAZOLIDINEDIONE DERIVATIVES Abstract A series of novel spiro-oxindole imidazolidine- dione derivatives have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductose inhibitors for the control of certain chronic diabetic complications. Preferred compounds include 6'-amino-spiro-[imidazolidine- 4,3'-indoline]-2,2',5-trione, 5'-chloro-7'-amino- spiro-[imidazolidine-4,3'-indoline]-2,2',5-trione, 1'-(3-pyridylmethyl)-5'-fluoro-spiro-[imidazolidine- 4,3'-indoline]-2,2',5-trione, 1'-(3-pyridylmethyl)- 5',7'-dichloro-spiro-[imidazolidine 4,3'-indoline]- 2,2',5-trione and spiro-[imidazolidine-4,3'-(6- azaindoline)]-2,2',5-trione. Methods for preparing these compounds from known starting materials are provided.
454883
Hutchison Alan J.
Pfizer Inc.
Smart & Biggar
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