Imidazolin-2-ylaminophenyl amides as ip antagonists

Details Imidazolin-2-ylaminophenyl amides as ip antagonists Imidazolin-2-ylaminophenyl amides as ip antagonists

C - Chemistry, Metallurgy

07

D

C07D 233/50 (2006.01) A61K 31/4168 (2006.01) A61P 11/00 (2006.01) A61P 13/02 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2522817

Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1 and R2 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

L'invention concerne des composés efficaces comme modulateurs du récepteur IP, en particulier comme antagonistes du récepteur IP, qui présentent la formule (I) dans laquelle A, R?1¿ et R?2¿ sont définis comme dans la spécification, ainsi que des isomères individuels, des mélanges racémiques ou non racémiques d'isomères et leurs sels ou solvates pharmaceutiquement acceptables. L'invention concerne également des compostions pharmaceutiques contenant lesdits composés et des méthodes permettant de les utiliser comme agents thérapeutiques.

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