Imidazolin derivatives and a method for producing the same...

Details Imidazolin derivatives and a method for producing the same... Imidazolin derivatives and a method for producing the same...

C - Chemistry, Metallurgy

07

D

C07D 233/06 (2006.01) A61K 31/415 (2006.01) C07D 233/08 (2006.01) C07D 233/26 (2006.01)

Patent

CA 2132017

(1) The imidazoline derivative represented by the following general formula (1) (see fig. I) where R1 is a substituent endowed with water solubility or fat solubility, particularly carboxyl group or carboxymethoxy group or a pharmaceutically acceptable salt thereof, (2) The method for producing the above-mentioned compound, and (3) A therapeutic agent containing as its active ingredient the above-mentioned imidazoline derivative or an imidazoline derivative wherein R1 indicated in the formula (1) is hydrogen atom. The imidazoline derivative set forth under (1) above is a novel substance; and this compound itself and its derivative having R1 as indicated in the general formula (1) is hydrogen atom are useful as a therapeutic agent for treatment of shock from the fall in blood pressure by virtue of their ability to remove excess NO which is the vascular endothelium-derived relaxing factor (EDRF).

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