Imidazolium salts useful as hypoglycemic agents

Details Imidazolium salts useful as hypoglycemic agents Imidazolium salts useful as hypoglycemic agents

C - Chemistry, Metallurgy

07

D

167/237, 260/315

C07D 233/56 (2006.01) A61K 31/415 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1266673

X-6502 Abstract The invention relates to imidazolium salts which are effective in lowering blood glucose levels in mammals. In particular, there is provided a compound of Formula (I) which is useful in lowering blood glucose levels: Image (I) in which: R1 is C1-C4 alkyl; R2 and R3, independently, are hydrogen or C1-C4 alkyl; each R4, independently is, -OR5, -NR6R7, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, or C1-C4 alkylthio; R5 is hydrogen or Image ; R6 is hydrogen, C1-C4 alkyl, or Image ; R7 is hydrogen or C1-C4 alkyl; each R8, independently, is C1-C4 alkyl or phenyl; Z is oxygen or sulfur; X is a therapeutically acceptable anion; and m is 0, 1 or 2.

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