C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61P 35/02 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2417148
Compounds of the formula (I) (see formula I) and pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.
L'invention porte sur des composés de la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, p, q, et n sont tels que définis dans la demande et sur leurs sels acceptables d'un point de vue pharmaceutique, ainsi que sur des esters hydrolysables in vivo. L'invention porte également sur des procédés de préparation et d'utilisation de ces composés comme médicaments, notamment des médicaments permettant d'avoir un effet inhibiteur sur le cycle cellulaire (anti-prolifération cellulaire) chez un être vivant à sang chaud tel que l'homme.
Breault Gloria Anne
Newcombe Nicholas John
Thomas Andrew Peter
Astrazeneca Ab
Smart & Biggar
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