C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/239.4
C07D 487/04 (2006.01) C07D 243/20 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 1073454
ABSTRACT OF THE DISCLOSURE: 1,2-Dihydro-6-phenyl-1H,4H-imidazo[1,2a][1,4]benzodia- zepin-1-ones having the general formula: (I) Image wherein R1 represents a hydrogen atom, a halogen atom, a nitro radical or a trifluoromethyl radical; R2, which may be at any position in the phenyl ring, represents a hydrogen or halogen atom; R3 represents a hydrogen atom or a methyl radical; and R4 and R5, which are the same or different, each represents a hydrogen atom, an alkyl radical containing from 1 to 5 carbon atoms, a hydroxyalkyl radical containing from 1 to 5 carbon atoms, an aminoalkyl or alkylaminoalkyl radical in which the alkyl moieties each contains from 1 to 5 carbon atoms, a phenyl radical, or a cycloalkyl radical containing from 3 to 8 carbon atoms, or R4 and R5 represent together with the nitrogen atom to which they are bound a heterocyclic radical selected from the group consisting of pyrrolidinyl, piperidino, morpholino, thio- morpholino, piperazin-1-yl, 4-alkyl-piperazin-1-yl, 4-hydroxyalkyl-piperazin-1-yl, 4-phenyl-piperazin-1-yl, 4-(1'-phenyl-5'-imidazolyl-4'-one) piperazin-1-yl and R - piperazin-1-yl radicals, in which R6 represents a cycloalkyl- alkyl radical containing from 3 to 8 carbon atoms, an alkenyl radical containing from 2 to 5 carbon atoms or a 4-dialkylphosphinyl alkyl radical, the alkyl moieties containing from 1 to 5 carbon atoms, and their pharmaceutically acceptable acid addition salts. These compounds have sedative, hypnotic, anxiolytic, tranquilizing, anticonvulsive and myorelaxant properties.
245850
Harrison Derek R.
Taylor John B.
Roussel-Uclaf
LandOfFree
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