Imidazolone anorectic agents: ii. phenyl derivatives

Details Imidazolone anorectic agents: ii. phenyl derivatives Imidazolone anorectic agents: ii. phenyl derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/00 (2006.01) A61K 31/415 (2006.01) A61K 31/4166 (2006.01) A61K 31/4178 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 233/30 (2006.01) C07D 233/32 (2006.01) C07D 233/70 (2006.01) C07D 233/74 (2006.01) C07D 233/76 (2006.01) C07D 233/78 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 411/00 (2006.01)

Patent

CA 2325587

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

On a effectué la synthèse d'une série d'antagonistes non peptidergiques de NPY contenant des dérivés phényles de composés d'imidazolone représentés par la formule (I). Ces composés et leurs analogues connus sont censés exercer une action anorexigène efficace, en tant qu'antagonistes du réflexe alimentaire induit par NPY, afin de favoriser la perte de poids et de traiter des troubles de la nutrition.

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