Imidazolopyridines and methods of making and using the same

Details Imidazolopyridines and methods of making and using the same Imidazolopyridines and methods of making and using the same

C - Chemistry, Metallurgy

07

D

C07D 237/00 (2006.01) A01N 43/00 (2006.01) A61K 31/535 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2497968

Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:

Les composés représentés par la formule (I) présentent une affinité étonnamment élevée pour Alk 5 et/ou Alk 4. Ils conviennent comme antagonistes de ces récepteurs pour la prévention et/ou le traitement de nombreuses maladies fibrosantes dont les troubles fibrogènes. Dans un mode de réalisation, l'invention concerne un composé de formule (I).

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