C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2669432
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment.
La présente invention porte sur des composés de formule (I), et sur des sels pharmaceutiquement acceptables ou tautomères de ceux-ci, qui sont inhibiteurs de poly(ADP-ribose)polymérase (PARP) et donc utiles dans le traitement du cancer, des maladies inflammatoires, des lésions de reperfusion, des états ischémiques, d'une attaque, d'une insuffisance rénale, de maladies cardiovasculaires, de maladies vasculaires autres que les maladies cardiovasculaires, du diabète sucré, de maladies neurodégénératives, d'infections rétrovirales, de lésions rétiniennes, de sénescence de la peau et de lésions cutanées induites par les UV, et en tant que chimio- ou radiosensibilisateurs pour le traitement du cancer.
Jones Philip
Kinzel Olaf
Koch Uwe
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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