Imidazolylphenyl amidines, processes for their preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/00 (2006.01) C07D 233/00 (2006.01) C07D 233/54 (2006.01) C07D 235/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 1171092

ABSTRACT OF THE DISCLOSURE The object of the present invention is new pharma- cologically active substituted imidazolylphenyl amidines of the following formula (I) Image in which R, R1 and R3, which may be the same of different represent a hydrogen atom or a lower alkyl group, and R2 represents a linear or branched alkyl, alkenyl or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group (optionally substituted by a halogen atom, a methyl, methoxy or methylenedioxy group) or a substituted or unsubstituted heterocycloalkyl or heterocyclic group which may also contain a further hetero atom; end non-toxic acid addition salts thereof. Processes for the preparation of the compounds of formula I and their intermediates as well as pharmaceutical compositions containing them are also objects of this invention. The new compounds are H2 receptor blocking agents which inhibit gastric acid secretion and are useful antiulcer agents.

391057

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