C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 471/22 (2006.01)
Patent
CA 2311456
Imidazonaphthyridine (I) and tetrahydroimidazonaphthyridine (II) compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed. R1 and R2 and A are as defined in the application.
L'invention concerne des composés à base d'imidazonaphthyridine (I) et de tetrahydroimidazonaphthyridine (II) activant la biosynthèse de cytokines telles que l'interféron et le facteur de nécrose des tumeurs. Les composés selon la présente invention possèdent des propriétés antivirales et antitumorales. L'invention concerne également des méthodes de préparation de ces composés et d'intermédiaires s'utilisant dans la préparation de ces composés. R¿1? et R¿2? sont comme définis dans l'application.
Crooks Stephen L.
Gerster John F.
Heppner Philip D.
Lindstrom Kyle J.
Marszalek Gregory J.
Gowling Lafleur Henderson Llp
Minnesota Mining And Manufacturing Company
Takeda Pharmaceutical Company Limited
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