Imidazopyrazine syk inhibitors

Details Imidazopyrazine syk inhibitors Imidazopyrazine syk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/5375 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 519/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2746023

Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating pa-tients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provid-ed. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

L'invention porte sur certaines imidazopyrazines et compositions pharmaceutiques de celles-ci. L'invention porte sur des méthodes de traitement de patients souffrant de certaines maladies et de certains troubles sensibles à l'inhibition de l'activité Syk, qui comprend l'administration à de tels patients d'une quantité d'au moins une entité chimique efficace pour réduire les signes ou symptômes de la maladie ou du trouble. L'invention porte également sur des méthodes de détermination de la présence ou de l'absence de la kynase Syk dans un échantillon.

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