Imidazopyrazines as cyclin dependent kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/498 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2627965

In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

La présente invention concerne une nouvelle classe de composés imidazo[1,2-a]pyrazine inhibant les kinases cycline-dépendantes (CDK), des procédés permettant de préparer de tels composés, des compositions pharmaceutiques renfermant un ou plusieurs de ces composés, des procédés destinés à la préparation de formulations pharmaceutiques renfermant un ou plusieurs de ces composés et des méthodes de traitement, de prévention, d~inhibition ou d~amélioration destinées à une ou plusieurs des maladies associées aux CDK qui utilisent ces composés et compositions pharmaceutiques.

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