Imidazopyrazines as cyclin dependent kinase inhibitors

Details Imidazopyrazines as cyclin dependent kinase inhibitors Imidazopyrazines as cyclin dependent kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2499756

In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds of formula (III) as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Dans plusieurs modes de réalisation de l'invention, on utilise une nouvelle classe de composés imidazo[1,2-a]pyrazine de formule (III) en tant qu'inhibiteurs de kinases dépendant de la cycline. L'invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques contenant un ou plusieurs composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs composés, et des méthodes de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladies associées aux CDK au moyen des composés ou des compositions pharmaceutiques de l'invention.

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