Imidazopyrazines as protein kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2669465

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds of following formula (1) as inhibitors of protein and/or Aurora kinases. methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions, such as cancer and leukemia.

Dans de nombreuses formes de réalisation, l'invention concerne une nouvelle classe de composés d'imidazopyrazine utilisés comme inhibiteurs de protéines kinases et/ou de kinases Aurora, des procédés de préparation de ces composés, des compositions pharmaceutiques comprenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés et des procédés utilisant ces composés ou compositions pharmaceutiques pour traiter, prévenir, inhiber ou soulager une ou plusieurs maladies associées aux protéines kinases et/ou aux kinases Aurora.

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