C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2654202
In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds of formula (I) as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
Dans de nombreux modes de réalisation, la présente invention concerne une nouvelle classe de composés d'imidazopyrazine représentés par la formule (I), utilisés en tant qu'inhibiteurs de kinases protéiques et/ou de kinases point de contrôle, des procédés de préparation de tels composés, des compositions pharmaceutiques contenant un ou plusieurs desdits composés, des procédés de préparation de formulations pharmaceutiques contenant un ou plusieurs desdits composés, et des méthodes de traitement, de prévention, d'inhibition, ou d'atténuation d'une ou plusieurs maladies associées aux kinases protéiques ou aux kinases point de contrôle à l'aide desdits composés ou desdites compositions pharmaceutiques.
Guzi Timothy J.
Paruch Kamil
Reddy Panduranga Adulla P.
Shih Neng-Yang
Siddiqui M. Arshad
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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