Imidazopyrazines for use as kinase inhibitors

Details Imidazopyrazines for use as kinase inhibitors Imidazopyrazines for use as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2756759

There is provided compounds of formula (I), wherein R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.

L'invention porte sur des composés de formule I, où R1, R2, R3, R4 et R5 ont les significations données dans la description, et sur des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesquels composés sont utiles dans le traitement de maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (par exemple une PI3-K et/ou mTOR) est désirée et/ou nécessaire, et particulièrement dans le traitement d'un cancer ou d'une maladie proliférative.

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