C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 5/50 (2006.01)
Patent
CA 2559444
The invention relates to substituted imidazopyridazine diones of general formula (I) wherein R1 to R4 have the designation defined in patent claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts of said diones, comprising valuable pharmacological properties, especially an inhibitive effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
L'invention concerne une imidazopyridazindione de formule générale (I) dans laquelle R?1¿ à R?4¿ sont tels que définis dans la revendication 1. L'invention concerne également les énantiomères, les diastéréoisomères de ce composé, ainsi que leurs mélanges et leurs sels, lesquels présentent des propriétés pharmacologiques précieuses, en particulier, un effet inhibiteur de l'activité de l'enzyme dipeptidylpeptidase-IV (DPP-IV).
Eckhardt Matthias
Himmelsbach Frank
Kauffmann-Hefner Iris
Langkopf Elke
Tadayyon Mohammad
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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