Imidazopyridazines, their production and use

Details Imidazopyridazines, their production and use Imidazopyridazines, their production and use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2091876

Imidazopyridazine Compounds, Their Production and Use ABSTRACT OF THE DISCLOSURE Novel compound of the general formula: Image [I] wherein R1 stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R2 and R3 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, provided that either R2 or R3 is a hydrogen atom, the other being an optionally substituted lower alkyl group, or R2 and R3 may, taken together with the adjacent -C=C- group, form a 5- to 7-membered ring; X stands for an oxygen atom or S(O)p (p stands for an integer from 0 to 2; Y stands for a group of the formula: Image (R4 and R5 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R6 and R7 each stands for a hydrogen atom, an optionally substituted lower lakyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R6 and R7 may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen-containing heterocyclic group; m stands for an integer from 0 to 4; and n stands for an integer from 0 to 4, or asalt thereof, which has excellent anti-PAF activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmaceutical compositions.

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