Imidazopyridine and related analogs as sirtuin modulators

Details Imidazopyridine and related analogs as sirtuin modulators Imidazopyridine and related analogs as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2726262

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Linvention concerne de nouveaux composés modulateurs de la sirtuine et leurs procédés dutilisation. Les composés modulateurs de la sirtuine peuvent être utilisés pour accroître la durée de la vie dune cellule et pour traiter et/ou prévenir un large éventail de maladies et de troubles incluant, par exemple, des maladies ou des troubles liés au vieillissement ou au stress, le diabète, lobésité, les maladies neurodégénératives, les maladies cardiovasculaires, les troubles de la coagulation, linflammation, le cancer, et/ou les bouffées congestives, ainsi que les maladies ou les troubles qui bénéficieraient dune activité mitochondriale accrue. Linvention concerne également des compositions renfermant un composé modulateur de la sirtuine en combinaison avec un autre agent thérapeutique.

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