Imidazopyridine compound

Details Imidazopyridine compound Imidazopyridine compound

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 3/12 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 15/06 (2006.01) A61P 15/08 (2006.01) A61P 15/10 (2006.01) A61P 17/16 (2006.01) A61P 19/06 (200

Patent

CA 2566184

An imidazopyridine compound represented by the formula [I]: [wherein R1 and R2 each independently represents C1-6 alkyl, etc.; R3 and R4 each independently represents hydrogen, methyl, etc.; Ar1 represents a divalent substituent, e.g., a mono- or dicyclic, 3- to 8-membered, aromatic or aliphatic, heterocyclic group; Ar2 represents an aromatic carbocyclic or aromatic heterocyclic group; W represents -(CH2)m-, etc.; and m is an integer of 1-10]. The compound functions as a melanin-concentrating hormone receptor antagonist and is useful as, e.g., a therapeutic agent for obesity, etc.

Composé imidazopyridine représenté par la formule [I] : [I] [dans laquelle R?1¿ et R?2¿ représentent chacun indépendamment un alkyle en C¿1-6?, etc. ; R?3¿ et R?4¿ représentent chacun indépendamment un hydrogène, un méthyle, etc. ; Ar¿1? représente un substituant divalent, par exemple un groupe hétérocyclique, aromatique ou aliphatique, monocyclique ou dicyclique ayant 3 à 8 éléments ; Ar¿2? représente un groupe carbocyclique aromatique ou hétérocyclique aromatique ; W représente -(CH¿2?)¿m?-, etc. ; et m est un nombre entier valant 1-10]. Le composé sert d'antagoniste du récepteur de l'hormone concentrant la mélanine et il est utile, par exemple, comme agent thérapeutique pour l'obésité, etc.

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