Imidazopyridine derivatives and process for preparation thereof

Details Imidazopyridine derivatives and process for preparation thereof Imidazopyridine derivatives and process for preparation thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/695 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2077419

An imidazopyridine derivative of the formula [I]: Image wherein R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkylsulfonyl or a group of the formula: Image (Z is oxygen atom or two hydrogen, R0 is substituted or unsubstituted lower alkyl, lower alkoxy, 5- or 6-membered heteromonocyclic, substituted or unsubstituted phenyl, hydrogen, substituted or unsubstitued amino or lower alkenyl), R3 is carboxyl or lower alkoxycarbonyl and Ring A is substituted or unsubstituted phenyl, and pharmaceutically acceptable salt thereof, and processes for preparation thereof, said imidazopyridine derivatives have excellent angiotensin II antagonistic activities and are useful in prophylaxis and treatment of hypertension.

Dérivé d'imidazopyridine de formule (I) Image , dans laquelle R1 est de l'hydrogène ou un alkyle inf., R2 est de l'hydrogène, un alkylsulfonyle inf. ou un groupe de formule Image (Z représente un atome d'oxygène ou deux hydrogènes, R0 est un alkyle inf. avec ou sans substitution, un alcoxy inf., un phényle hétéromonocyclique à 5 ou 6 chaînons, avec ou sans substitution, un hydrogène, un alcényle inf. ou un amino avec ou sans substitution), R3 est un carboxyle ou un alcoxycarbonyle inf., et le cycle A est un phényle avec ou sans substitution; sel de ce dérivé, acceptable en pharmacie, et méthodes pour préparer ces composés. Lesdits dérivés d'imidazopyridine sont d'efficaces antagonistes de l'angiotensine II et sont utiles pour la prévention et le traitement de l'hypertension.

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