Imidazopyridine derivatives as phosphodiesterase vii inhibitors

Details Imidazopyridine derivatives as phosphodiesterase vii inhibitors Imidazopyridine derivatives as phosphodiesterase vii inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 11/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)

Patent

CA 2388729

The invention relates to compounds of formula (I), wherein R1 means CONR4R5; R2 means H or A; R3 means Hal; R4 and R5 each mean H or A1, independently of each other; Hal is F, Cl, Br or I, A means alkyl with 1-4 C atoms, A1 means alkyl with 1-10 C atoms; and X means alkylene with 1-4 C atoms, an ethylene group also being replaceable by a double or triple bond, and their physiologically compatible salts and/or solvates, used as phosphodiesterase VII inhibitors. The invention also relates to their use for producing a medicament.

La présente invention concerne des composés de formule (I) dans laquelle R?1¿ est CONR?4¿R?5¿; R?2¿ est H ou A; R?3¿ est Hal; R?4¿, R?5¿ sont indépendamment H ou A?1¿; Hal est F, Cl, Br ou I; A est alkyle comprenant 1-4 atomes de C; A?1¿ est alkyle comprenant 1-10 atomes de C; X est alkylène comprenant 1-4 atomes de C, un groupe éthylène pouvant également être remplacé par une double ou une triple liaison. Cette invention concerne également les sels et/ou les solvates admissibles du point de vue physiologique, ces composés étant utilisés en tant qu'inhibiteurs de la phosphodiestérase VII. Cette invention concerne également l'utilisation de ces composés pour la préparation d'un produit pharmaceutique.

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