Imidazopyridine substituted tropane derivatives with ccr5...

Details Imidazopyridine substituted tropane derivatives with ccr5... Imidazopyridine substituted tropane derivatives with ccr5...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4188 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2540834

The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.

L'invention concerne des composés de formule (I) dans laquelle R?1¿ et R?2¿ sont tels que définis dans le présent fascicule. Ces composés sont des modulateurs, notamment des antagonistes, de l'activité des récepteurs CCR5 des chimiokines. Les modulateurs du récepteur CCR5 peuvent être utiles dans le traitement des diverses maladies et affections inflammatoires, et dans le traitement de l'infection par le VIH et les rétrovirus génétiquement apparentés.

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