Imidazopyridine thrombin inhibitors

Details Imidazopyridine thrombin inhibitors Imidazopyridine thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 239/42 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2333040

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having structure (I) or (II), wherein Y1 and Y2 are independently selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 alkoxy, C3-7 cycloalkyl, halogen, and trifluoromethyl; and A is (III), (IV), (V), or (VI).

L'invention concerne des composés pouvant inhiber efficacement la thrombine et des occlusions thrombotiques associées et présentant la structure (I) ou (II) dans laquelle Y?1¿ et Y?2¿ sont sélectionnés, indépendamment, dans le groupe constitué par hydrogène, alkyle C¿1-4?, alcoxy C¿1-4?, cycloalkyle C¿3-7?, halogène et trifluorométhyle; et A présente les structures (III), (IV), (V) ou (VI).

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