C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/435 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2082414
P9028.WPF ABSTRACT OF THE DISCLOSURE The imidazopyridines compounds of the present invention are serotonergic 5-HT3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
Becker Daniel P.
Flynn Daniel L.
Moormann Alan E.
Nosal Roger
Villamil Clara I.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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