Imidazopyrimidines and imidazopyridines for the treatment of...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2294117

Corticotropin releasing factor (CRF) antagonists of formula (I) and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart- related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

L'invention concerne des antagonistes du facteur de libération de la corticotrophine (CRF) représentés par la formule (I), et leur utilisation pour traiter des troubles psychiatriques et des affections neurologiques, des troubles liés à l'anxiété, des troubles de stress post-traumatique, des troubles de paralysie supranucléaire et de l'alimentation, ainsi que des troubles immunitaires, cardiovasculaires ou cardiaques, et une hypersensibilité du côlon associée à des troubles psychopathologiques et au stress chez les mammifères.

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