Imidazoquinazoline compounds and their preparation and use

Details Imidazoquinazoline compounds and their preparation and use Imidazoquinazoline compounds and their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2125854

2125854 9313103 PCTABS00024 Imidazoquinazoline compounds having formula (I), wherein Q is (a), (b), (c), or (d) -COOR8 or -CN; wherein R1 is H, alkyl, unsubstituted or substituted cycloalkyl, alkoxy, alkoxyalkyl or CF3; R8 is alkyl; R2 and R3 independently are H, alkyl optionally substituted, cycloalkyl, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonylalkyl, formylalkyl, or an acetal thereof, or R2 and R3 together with the N-atom form a 4-6 membered cyclic amino group in which ring system one or more of the carbon atoms may be exchanged with N,O or S, sulphinyl, sulphonyl or carbonyl or an acetal thereof, each of these ring systems optionally being substituted; R4, R5, R6 and R7 independently are H, OH, halogen, CF3 NO2, NH2, CN, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl or alkoxycarbonyl. The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, in improving the cognitive function of the brain of mammals, or as benzodiazepine antagonists.

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