Imidazoquinazoline derivatives

Details Imidazoquinazoline derivatives Imidazoquinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2148082

-99- ABSTRACT The present invention relates to imidazoquinazoline derivatives represented by the general formula (I): Image (I) or pharmacologically acceptable salts thereof. The compounds of the present invention have strong and selective cGMP-specific PDE inhibitory activity and are useful for treating or ameliorating cardiovascular diseases such as thrombosis, angina pectoris, hypertension, arterial sclerosis and the like, as well as asthma and the like.

Dérivé d'imidazoquinazoline représenté par la formule générale (I) ou un sel pharmacologiquement acceptable de celui-ci, formule dans laquelle R<1> et R<2> peuvent être identiques ou différents et représentent chacun hydrogène, alkyle inférieur, alkényle inférieur, aryle, etc.; R<3> représente hydrogène, alkyle inférieur, cycloalkyle, alkényle inférieur, aryle, etc.; et X représente O ou S. Ce composé a une puissante activité sélective d'inhibition PDE spécifique à cCMP et est utile pour le traitement de maladies cardiovasculaires telles que thrombose, angine de poitrine, hypertension et artériosclérose, asthme, etc.

Affiliated with

Also associated with

Rating

Imidazoquinazoline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazoquinazoline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazoquinazoline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1534033