Imidazoquinoline derivative

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 471/06 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2196167

A specified imidazoquinoline derivative represented by general formula (I) or a salt thereof, capable of inhibiting acidophilia and hence being useful as a preventive and/or a remedy for diseases causing acidophilia, wherein Q represents optionally substituted phenyl, pyridyl or furyl; Y represents hydrogen or is combined with Z to represent oxygen, methylene or a group of the formula (II): =N-OR1, and Z represents hydrogen, hydroxymethyl, carboxymethyl, 2-oxo-1-pyrrolidinyl or a group of the formula (III): -A-R2, wherein A represents oxygen, sulfur or -NH-.

L'invention concerne un dérivé d'imidazoquinoléine représenté par la formule générale (I), ou bien un sel de celui-ci, permettant d'inhiber l'acidophilie et donc d'être utile comme agent prophylactique et/ou curatif pour des maladies provoquant l'acidophilie. Dans ladite formule, Q représente phényle, pyridyle ou furyle éventuellement substitués; Y représente hydrogène ou est associé à Z pour représenter oxygène, méthylène ou un groupe de formule (II): =N-OR?1¿, et Z représente hydrogène, hydroxyméthyle, carboxyméthyle, 2-oxo-1-pyrrolidinyle ou un groupe de formule (III): -A-R?2¿ où A représente oxygène, soufre ou bien -NH-.

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