Imidazothiazole derivatives

Details Imidazothiazole derivatives Imidazothiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/4985 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 513/10 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2672565

It is intended to provide novel compounds which inhibit the interaction between Mdm2 (murine double minute 2) protein and p53 protein and show an antitumor activity. Imidazothiazole derivatives having various substituents as represented by the following general formula (1), which inhibit the interaction between Mdm2 protein and p53 protein and show an antitumor activity, are provided, wherein R1, R2, R3, R4 and R5 in the general formula (1) are each as defined in the description.

L'invention propose de nouveaux composés qui inhibent l'interaction entre la protéine Mdm2 (murine double minute 2) et la protéine p53 et présentent une activité anti-tumorale. Des dérivés d'imidazothiazole ayant divers substituants tels que représentés par la formule générale suivante (1), qui inhibent l'interaction entre la protéine Mdm2 et la protéine p53 et montrent une activité anti-tumorale, sont proposés. Dans la formule générale (1), R1, R2, R3, R4 et R5 sont chacun tels que définis dans la description.

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