Imidazothiazole derivatives having proline ring structure

Details Imidazothiazole derivatives having proline ring structure Imidazothiazole derivatives having proline ring structure

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/499 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2750009

[Problem to be Solved] There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. [Solution] The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: ( see formula 1) wherein R1, R2, R3, R4, R5, R6, R7, Ar1, and Ar2 in formula (1) respectively have the same meanings as defined in the specification. [Selected Drawing] None

L'invention concerne un composé qui inhibe l'interaction entre la protéine Mdm2 (murine double minute 2) et la protéine p53, et présente une activité antitumorale. L'invention concerne, de manière spécifique, un dérivé d'imidazothiazole représenté par la formule (1) et comprenant des substituants variés. Le dérivé d'imidazothiazole inhibe l'interaction entre la protéine Mdm2 et la protéine p53 et présente une activité antitumorale. (Dans la formule (1), R1, R2, R3, R4, R5, R6, R7, Ar1 et Ar2 sont tels que définis dans la description.)

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