Imidazotriazines and imidazopyrimidines as kinase inhibitors

Details Imidazotriazines and imidazopyrimidines as kinase inhibitors Imidazotriazines and imidazopyrimidines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2669991

The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.

La présente invention concerne des imidazo[1,2-b][1,2,4]triazines et des imidazo[1,2-a]pyrimidines, et des compositions pharmaceutiques de ces composés, qui représentent des inhibiteurs de kinases telles que c-Met et qui sont utiles dans le traitement d'un cancer et d'autres maladies associées aux perturbations des voies des kinases.

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