Imide derivatives, and their production and use

Details Imide derivatives, and their production and use Imide derivatives, and their production and use

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 209/48 (2006.01) C07D 275/06 (2006.01) C07D 401/08 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/08 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 491/18 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2046429

The present invention is directed to an imide compound of the formula: (see Formula I) wherein Z is a group of the formula: (see Formula II) in which B is a carbonyl group or a sulfonyl group, R1, R2, R3 and R4 each represent a hydrogen atom or a lower alkyl group, or R1 and R2 or R1 and R3 may be combined together to form a non-aromatic hydrocarbon ring or R1 and R3 may be combined together to form an aromatic ring, said non-aromatic hydrocarbon ring being optionally bridged with a lower alkylene group or an oxygen atom therein and said aromatic ring, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and n is an integer of 0 or 1; D is a group of the formula: -(CH2)p-A-(CH2)q- in which A is a non-aromatic hydrocarbon ring optionally bridged with a lower alkylene group or an oxygen atom, said non-aromatic hydrocarbon ring and said lower alkylene group being each optionally substituted with at least one lower alkyl, and p and q are each an integer of 0, 1 or 2; and -2- Ar is an aromatic group, a heterocyclic aromatic group, a benzoyl group, a phenoxy group or a phenylthio group and G is ~N-, ~CH- or ~COH- or Ar is a biphenyl- methylidene group and G is ~C=, all of the above groups being each optionally substituted with at least one of lower alkyl, lower alkoxy and halogen; and its acid addition salts. The compounds of the present invention are useful as an antipsychotic agent.

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