Imides as pde iii, pde iv and tnf inhibitors

Details Imides as pde iii, pde iv and tnf inhibitors Imides as pde iii, pde iv and tnf inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) C07D 207/408 (2006.01) C07D 207/448 (2006.01) C07D 209/46 (2006.01) C07D 209/62 (2006.01) C07D 405/02 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2241688

Novel amides are inhibitors of TNF.alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3-phthalimido-3-(3- cyclopentyloxy-4-methoxyphenyl)propionamide.

L'invention concerne de nouveaux amides qui inhibent le facteur de nécrose tumorale (TNF).alpha. et la phosphodiestérase. On peut utiliser ces amides pour traiter la cachéxie, le choc endotoxique, la réplication de rétro-virus, l'asthme et les pathologies inflammatoires. Dans une variante type, les amides en question se présentent sous la forme de 3-phtalimido-3-(3-cyclopentyloxy-4-méthoxyphényl)propionamide.

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