Imidoester cross-linked hemoglobin compositions

Details Imidoester cross-linked hemoglobin compositions Imidoester cross-linked hemoglobin compositions

A - Human Necessities

61

K

A61K 38/42 (2006.01) A61K 35/18 (2006.01) C07K 14/805 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093650

2093650 9209630 PCTABS00013 An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13 mM Hg and predominantly in tetramer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.

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