Imine-forming polysaccharides, preparation thereof and the...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 39/39 (2006.01) A61K 47/36 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2305599

The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or via a bifunctional linker. The conjugates are useful as immuno-stimulants and adjuvants.

La présente invention concerne des conjugués de polysaccharide renfermant un polysaccharide qui se fixe à des récepteurs de surface présents sur des cellules présentant l'antigène, ce polysaccharide étant conjugué à un ou plusieurs composés avec des groupes carbonyles stables liés par covalence, soit directement soit par l'intermédiaire d'un liant bifonctionnel. Ces conjugués sont utiles en tant qu'immunostimulants et adjuvants.

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