Imino acid derivatives for use as inhibitors of matrix...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 209/52 (2006.01) A61K 31/395 (2006.01) A61K 31/403 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/14 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2512346

The compounds of formula (I) are useful for preparing drugs used in the prophylaxis and therapy of diseases which are associated with an increased matrix metalloproteinase activity. Examples of such diseases are degenerative articular diseases such as osteoarthroses, spondyloses, chondroporosis after articular trauma or prolonged joint immobilization after meniscus or patella injuries or rupture of a ligament, or a disease of the connective tissue such as collagenoses, periodontal diseases, defective wound healing, or a chronic diseases of the locomotor system such as inflammatory, immunologically or metabolically mediated acute or chronic arthritides, arthropathies, myalgias or disorders of the bone metabolism or an ulceration, atherosclerosis or stenosis or an inflammatory disease or a tumor disease, tumor metastatic spread, cachexia, anorexia or septicaemic shock.

L'invention concerne des composés de formule (I). Ces composés peuvent être utilisés pour produire des médicaments servant à prévenir et traiter des maladies dont l'évolution est liée à une activité accrue de métalloprotéinases matricielles. Parmi ces maladies figurent, par exemple, des maladies articulaires dégénératives telles que des arthroses, des spondylarthroses, une chondrolyse après un traumatisme articulaire ou une immobilisation articulaire prolongée suite à des lésions méniscales ou patellaires ou des déchirures ligamentaires, ou une maladie du tissu conjonctif, par ex. des collagénoses, des parodontopathies, des troubles de la cicatrisation, ou une maladie chronique de l'appareil moteur, par ex. des arthrites, des arthropathies ou des myalgies inflammatoires aiguës ou chroniques, d'origine immunologique ou métabolique, ou des troubles du métabolisme osseux, ou une ulcération, une athérosclérose ou une sténose, ou une maladie inflammatoire ou une maladie cancéreuse, la formation de métastases tumorales, la cachexie, l'anorexie ou un choc septique.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Imino acid derivatives for use as inhibitors of matrix... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imino acid derivatives for use as inhibitors of matrix..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imino acid derivatives for use as inhibitors of matrix... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1934153

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.