C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/54 (2006.01) A61K 31/357 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) C07D 317/14 (2006.01)
Patent
CA 2518986
A compound represented by the following general formula (I), its salt, its solvate or its N-oxide or prodrugs thereof: (I) wherein R1 and R2 represent each an optionally substituted cyclic group, etc.; W is a spacer having from 1 to 6 carbon atoms in its main chain; X represents -O-, etc.; A represents an optionally substituted cyclic group; Y is a spacer having from 1 to 6 carbon atoms in its main chain, etc.; and Z represents an acidic group. Because of having an activity of controlling peroxisome proliferator-activated receptors, the compounds are useful as preventives/remedies for metabolic errors such as hypercholesteremia and hyperlipoproteinemia, hyperlipemia, arteriosclerosis, hypertension, circulatory diseases, hyperphagia, ischemic heart diseases and so on, HDL cholesterol-elevating agents, LDL cholesterol and/or VLDL cholesterol-lowering agents, and drugs for relieving risk factors of diabetes and metabolic syndrome.
L'invention concerne un composé de formule générale (I), y compris sel, solvate ou N-oxyde ou bien promédicament correspondant. R?1¿et R?2¿ sont chacun éventuellement un groupe cyclique substitué, etc. W est un espaceur ayant entre 1 et 6 atomes de carbone dans sa chaîne principale. X est O-, etc. A est un groupe cyclique éventuellement substitué. Y est espaceur ayant entre 1 et 6 atomes de carbone dans sa chaîne principale, etc. Et Z est un groupe acide. Parce qu'ils contrôlent les récepteurs de peroxysome activés par proliférateur, les composés en question sont utiles pour la prévention et le traitement des anomalies du métabolisme du type hypercholestérémie et hyperlipoprotéinémie, hyperlipémie, artériosclérose, hypertension, maladies circulatoires, hyperphagie, cardiopathie ischémique, etc. agents augmentant le cholestérol HDL, agents diminuant le cholestérol LDL et/ou VLDL, et médicaments atténuant les facteurs de risque du diabète et du syndrome métabolique.
Ishida Akiharu
Kido Tomoyuki
Kitamine Tetsuya
Kusuda Shinya
Nakayama Yoshisuke
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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