Iminochlorin aspartic acid derivatives

Details Iminochlorin aspartic acid derivatives Iminochlorin aspartic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 31/40 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2268968

The present invention provides an iminochlorin aspartic acid derivative represented by the following formula (I): (see formula I) Wherein Asp represents an aspartic acid residue, or a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a photosensitizer for photophysico- chemical diagnosis and therapy of cancer, because it has a high accumulability to cancerous cells, reactivity to external energy and a cancerous cell destroying effect which is effective even againt cancers developing in deep site, while it is rapidly excreted from normal cells and therefore causes no damage thereto.

L'invention concerne des dérivés d'acide iminochlorinaspartique représentés par la formule générale (I) et des sels pharmacologiquement acceptables de ceux-ci, formule dans laquelle Asp représente aspartate. Ces composés sont utiles en tant que photosensibilisants dans le diagnostic photophysique et le traitement du cancer, et, se caractérisent en ce qu'ils s'accumulent sélectivement dans les cellules cancéreuses, qu'ils sont sensibles à l'énergie extérieure, qu'ils ont un effet cytocide, une action thérapeutique même sur un cancer avancé et qu'ils sont excrétés rapidement des tissus normaux sans que ceux-ci soient endommagés.

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