Immediate-release tablet formulations of a thrombin receptor...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/20 (2006.01) A61K 31/4418 (2006.01) A61K 31/444 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2656395

Immediate-release formulations for oral administration of a thrombin receptor antagonist are provided. Certain formulations of higher API loading demonstrate sufficient moisture uptake after storage at stressed conditions to retard dissolution. The formulations of the present invention incorporate either lower API loading or elevated disintegrant-to-API ratios, found necessary to achieve disintegration rates required for immediate-release performance.

L'invention concerne des préparations à libération immédiate d'un antagoniste des récepteurs de la thrombine, destinées à être administrées par voie orale. Certaines préparations renfermant une dose de principe actif plus élevée souffrent d'une absorption d'humidité, après une période de stockage donnée dans des conditions difficiles, pouvant retarder la dissolution. Les préparations de la présente invention peuvent soit renfermer une dose de principe actif plus faible, soit présenter des rapports délitant/principe actif élevés, conditions nécessaires pour obtenir des vitesses de désintégration suffisantes pour une libération immédiate.

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